Determinação computacional de novos biomarcadores do cancro do cólon

Name: Determinação computacional de novos biomarcadores do cancro do cólon
Brand: Edicoes Nosso Conhecimento
SKU: 9786630007015
Price: 5314.0 INR
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by Ashok Palaniappan

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ISBN13: 9786630007015
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: May 31, 2026
Pages: 56
Original Price: GBP 42.0
Language: Portuguese
Edition: N/A
Item Weight: 87 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Este trabalho constitui uma nova abordagem da biologia de sistemas para decifrar a identidade de genes e produtos gen�ticos espec�ficos envolvidos na evolu��o do cancro do c�lon, desde a tumorig�nese at� � met�stase. Foi realizada uma meta-an�lise baseada nos est�gios de dados de sequencia��o do genoma tumoral de dom�nio p�blico e foram empregues m�ltiplas abordagens para identificar novos genes respons�veis pela inicia��o, progress�o e met�stase do cancro do c�lon. Os genes impulsionadores espec�ficos de cada est�gio, identificados por consenso, serviram de base para a constru��o de redes ad hoc espec�ficas de cada est�gio, que foram analisadas quanto � centralidade dos genes, ao agrupamento de sub-redes e ao enriquecimento de processos de ontologia gen�tica. Foram identificados nove novos genes impulsionadores como centrais para o in�cio e a tumorig�nese do cancro do c�lon. Tr�s, quatro e tr�s novos genes impulsionadores foram identificados como n�s centrais para a progress�o para os est�gios II, III e IV, respetivamente. Os nossos resultados foram corroborados por m�dulos de sub-redes e pela an�lise ontol�gica. O nosso estudo revelou potenciais biomarcadores de diagn�stico para o cancro do c�lon, bem como novos alvos farmacol�gicos espec�ficos por est�gio para uma interven��o racional. A nossa metodologia � extens�vel � an�lise de outros tipos de cancro, a fim de colmatar as lacunas no nosso conhecimento.

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