Determinazione computazionale di nuovi biomarcatori del cancro al colon

Name: Determinazione computazionale di nuovi biomarcatori del cancro al colon
Brand: Edizioni Sapienza
SKU: 9786630081244
Price: 5314.0 INR
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by Ashok Palaniappan

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ISBN13: 9786630081244
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: May 31, 2026
Pages: 52
Original Price: GBP 42.0
Language: Italian
Edition: N/A
Item Weight: 82 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Questo lavoro rappresenta un nuovo approccio di biologia dei sistemi volto a decifrare l'identit� di geni specifici e dei loro prodotti coinvolti nella progressione del cancro del colon, dalla tumorigenesi fino alla metastasi. � stata condotta una meta-analisi basata sugli stadi clinici dei dati di sequenziamento del genoma tumorale disponibili nel dominio pubblico e sono stati impiegati diversi approcci per individuare nuovi geni che guidano l'insorgenza, la progressione e la metastasi del cancro del colon. I geni driver specifici per stadio individuati per consenso hanno portato alla costruzione di reti ad hoc specifiche per stadio, che sono state analizzate per la centralit� dei geni, il raggruppamento delle sottoreti e l'arricchimento dei processi di ontologia genica. Sono stati identificati nove nuovi geni driver come centrali per l'insorgenza e la tumorigenesi del cancro del colon. Tre, quattro e tre nuovi geni driver sono stati identificati come hub per la progressione rispettivamente allo stadio II, allo stadio III e allo stadio IV. I nostri risultati sono stati supportati da moduli di sottoreti e dall'analisi ontologica. Il nostro studio ha individuato potenziali biomarcatori diagnostici per il cancro del colon, nonch� nuovi bersagli farmacologici specifici per stadio per un intervento razionale. La nostra metodologia � estendibile all'analisi di altri tipi di cancro per colmare le lacune nelle nostre conoscenze.

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