I cambiamenti nell'acetilazione delle proteine SR possono influenzare lo splicing alternativo?

Name: I cambiamenti nell'acetilazione delle proteine SR possono influenzare lo splicing alternativo?
Brand: Edizioni Sapienza
SKU: 9786630084696
Price: 5442.0 INR
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ISBN13: 9786630084696
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: May 18, 2026
Pages: 64
Original Price: GBP 43.0
Language: Italian
Edition: N/A
Item Weight: 100 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Il fenotipo e la funzione cellulare sono determinati dal proteoma cellulare. All'interno del proteoma cellulare esistono processi in grado di alterarne significativamente la composizione. Uno di questi processi � lo splicing alternativo. Lo splicing consiste nella rimozione degli introni da una sequenza di pre-mRNA e nell'unione delle sequenze di pre-mRNA rimanenti, chiamate esoni. Lo splicing alternativo modifica la combinazione introne-esone e pu� formare nuovi prodotti a partire dalla diversa disposizione delle sequenze codificanti. La disregolazione dello splicing alternativo � stata documentata in molte malattie umane. La regolazione dello splicing alternativo coinvolge una complessa rete di proteine e RNA. Le proteine con ripetizioni serina-arginina (SR) sono una famiglia nota di proteine regolatrici che si legano all'interno degli esoni per promuovere l'inclusione degli esoni nel trascritto di mRNA maturo. L'attivit� delle proteine SR � regolata da modificazioni post-traduzionali, fosforilazione e acetilazione. Lo studio allegato propone un possibile meccanismo di come l'acetilazione delle proteine SR possa alterare lo splicing alternativo. Questo libro dovrebbe essere utile a chiunque sia interessato alla regolazione dello splicing alternativo e alle proteine SR.

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