Können Veränderungen in der Acetylierung von SR-Proteinen das alternative Spleißen beeinflussen?

Name: Können Veränderungen in der Acetylierung von SR-Proteinen das alternative Spleißen beeinflussen?
Brand: Verlag Unser Wissen
SKU: 9786630077018
Price: 5442.0 INR
Availability: InStock

by Heather E. Knupp

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ISBN13: 9786630077018
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: May 18, 2026
Pages: 64
Original Price: GBP 43.0
Language: German
Edition: N/A
Item Weight: 100 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Der zellul�re Ph�notyp und die Zellfunktion werden durch das zellul�re Proteom bestimmt. Innerhalb des zellul�ren Proteoms gibt es Prozesse, die das Potenzial haben, die Zusammensetzung des Proteoms erheblich zu ver�ndern. Ein solcher Prozess wird als alternatives Splei en bezeichnet. Beim Splei en werden Introns aus einer pr�-mRNA-Sequenz entfernt, und die verbleibenden pr�-mRNA-Sequenzen, die als Exons bezeichnet werden, werden miteinander verbunden. Alternatives Splei en modifiziert die Intron-Exon-Kombination und kann durch die unterschiedliche Anordnung der kodierenden Sequenzen neue Produkte bilden. Eine Fehlregulation des alternativen Splei ens wurde bei vielen menschlichen Erkrankungen dokumentiert. Die Regulation des alternativen Splei ens umfasst ein komplexes Netzwerk aus Proteinen und RNA. Serin-Arginin-Repeat (SR)-Proteine sind eine bekannte Familie regulatorischer Proteine, die innerhalb von Exons binden, um die Einbeziehung von Exons in das reife mRNA-Transkript zu f�rdern. Die Aktivit�t von SR-Proteinen wird durch posttranslationale Modifikationen, Phosphorylierung und Acetylierung reguliert. Die beigef�gte Studie schl�gt einen m�glichen Mechanismus vor, wie die Acetylierung von SR-Proteinen das alternative Splei en ver�ndern kann. Dieses Buch d�rfte f�r alle hilfreich sein, die sich f�r die Regulation des alternativen Splei ens und f�r SR-Proteine interessieren.

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