L'asse ipotalamo-ipofisi-surrene (HPA) di fronte all'envenomazione

Name: L'asse ipotalamo-ipofisi-surrene (HPA) di fronte all'envenomazione
Brand: Edizioni Sapienza
SKU: 9786208905194
Price: 7708.0 INR
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ISBN13: 9786208905194
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: May 29, 2025
Pages: 148
Original Price: GBP 69.51
Language: Italian
Edition: N/A
Item Weight: 209 grams
BISAC Subject(s): Life Sciences / Biology

About The Book

L'asse ipotalamo-ipofisi-surrene(HPA) � un attore chiave nell'interazione tra il sistema neuroendocrino e il sistema immunitario. Questo studio esplora l'impatto del veleno diAndroctonus australis hector(Aah) sull'attivazione dell'asse HPA, a seconda della fase giorno-notte. Utilizzando un approccio sperimentale, analizziamo le risposte infiammatorie e il danno ossidativo indotti dal veleno, evidenziando la modulazione esercitata dal corticosterone. L'aumento dei livelli sierici di ACTH e corticosterone indica una maggiore attivazione dell'HPA, pi� pronunciata durante la fase attiva. Allo stesso tempo, il veleno provoca danni ossidativi e alterazioni cardio-epatiche, amplificate dall'eccessiva produzione di specie reattive dell'ossigeno e dell'azoto. Il coinvolgimento del corticosterone in questi disturbi � stato valutato utilizzando un test di soppressione con desametasone. Questi risultati evidenziano una risposta infiammatoria e metabolica modulata dai ritmi circadiani, sottolineando l'importanza dell'HPA nella gestione dello stress tossico.

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