Le calcium: au-delà de l'os - de l'homéostasie à la maladie
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Le calcium est un d�terminant fondamental de la physiologie humaine, r�gissant l'int�grit� structurelle et un large �ventail de fonctions cellulaires. Cet ouvrage propose une exploration compl�te de la biologie du calcium, en commen�ant par son hom�ostasie syst�mique, ses sources alimentaires et les m�canismes d'absorption intestinale qui garantissent une biodisponibilit� ad�quate. Il passe ensuite aux perspectives cliniques, en soulignant le r�le essentiel du calcium en tant que second messager dans la signalisation neuronale et l'architecture complexe de ses canaux dans le syst�me nerveux central. La discussion examine ensuite comment une r�gulation calcique perturb�e contribue � des troubles majeurs, notamment la maladie d'Alzheimer, la maladie de Parkinson, le diab�te et le cancer. En outre, le texte aborde des conditions cliniquement significatives telles que l'hypercalc�mie d'origine maligne et �value les implications cardiovasculaires de la suppl�mentation en calcium. Ensemble, ces chapitres int�grent les connaissances mol�culaires et la pertinence clinique, offrant une compr�hension coh�rente du calcium dans la sant� et la maladie.
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