Neurofarmacologia da Coccinia grandis - Neuropatia diabética

Name: Neurofarmacologia da Coccinia grandis - Neuropatia diabética
Brand: Edicoes Nosso Conhecimento
SKU: 9786209834301
Price: 10465.0 INR
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by Bhaskar Nagilla

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ISBN13: 9786209834301
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: March 27, 2026
Pages: 260
Original Price: USD 116.0
Language: Portuguese
Edition: N/A
Item Weight: 354 grams
BISAC Subject(s): Life Sciences / Zoology / General

About The Book

A dor neurop�tica diab�tica � uma condi��o extremamente debilitante e geralmente dif�cil de tratar. O extrato metan�lico de Coccinia grandis foi testado quanto � sua a��o analg�sica e anti-inflamat�ria num modelo de rato com neuropatia diab�tica induzida por STZ. A atividade inflamat�ria aguda foi estudada pelo teste de dor de Randal. Foram determinados no nervo ci�tico e no c�rebro os mediadores nociceptivos, a coordena��o neuromuscular, fatores eletrofisiol�gicos e inflamat�rios, como a ciclo-oxigenase e a PG peroxidase, que contribuem para a dor neurop�tica. A atividade analg�sica foi estudada em ratos utilizando os testes da placa quente e de retirada da cauda (tail-flick). Foram determinadas altera��es neuroqu�micas, como glicose, frutose, sorbitol e glutationa reduzida no nervo ci�tico e no c�rebro. Enzimas como a hexoquinase, a aldose redutase, a sorbitol desidrogenase e a glicose-6-fosfato desidrogenase tamb�m foram determinadas ap�s 3 semanas. Foi tamb�m estudada a altera��o histopatol�gica do nervo ci�tico e do c�rebro. Foi estudada a patologia de todos os �rg�os vitais, como rim, f�gado e intestino. Em conclus�o, o extrato da folha de Coccinia grandis possui atividades anti-inflamat�rias e analg�sicas, efeito antidiab�tico e n�o t�xico.

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