Neurofarmacologia della Coccinia grandis - Neuropatia diabetica

Name: Neurofarmacologia della Coccinia grandis - Neuropatia diabetica
Brand: Edizioni Sapienza
SKU: 9786209829185
Price: 10465.0 INR
Availability: InStock

by Bhaskar Nagilla

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ISBN13: 9786209829185
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: March 27, 2026
Pages: 260
Original Price: USD 116.0
Language: Italian
Edition: N/A
Item Weight: 354 grams
BISAC Subject(s): Life Sciences / Zoology / General

About The Book

Il dolore neuropatico diabetico � una condizione estremamente debilitante e solitamente difficile da trattare. L'estratto metanolico di Coccinia grandis � stato testato per la sua azione analgesica e antinfiammatoria su un modello di ratto con neuropatia diabetica indotta da STZ. L'attivit� infiammatoria acuta � stata studiata con il test del dolore di Randal. I mediatori nocicettivi, la coordinazione neuromuscolare, elettrofisiologici e infiammatori come la ciclossigenasi e la PG perossidasi, che contribuiscono al dolore neuropatico, sono stati determinati nel nervo sciatico e nel cervello. L'attivit� analgesica � stata studiata nei ratti utilizzando i test della piastra calda (hot plate) e del colpo di coda (tail-flick). Alterazioni neurochimiche come glucosio, fruttosio, sorbitolo e glutatione ridotto sono state determinate nel nervo sciatico e nel cervello. Dopo 3 settimane sono stati determinati anche enzimi come esochinasi, aldoso reduttasi, sorbitolo deidrogenasi e glucosio-6-fosfato deidrogenasi. � stata inoltre studiata un'alterazione istopatologica del nervo sciatico e del cervello. � stata studiata la patologia di tutti gli organi vitali come reni, fegato e intestino. In conclusione, l'estratto di foglie di Coccinia grandis possiede attivit� antinfiammatorie e analgesiche, effetto antidiabetico e non tossico.

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