Neurofarmakologia Coccinia grandis - Neuropatia cukrzycowa

Name: Neurofarmakologia Coccinia grandis - Neuropatia cukrzycowa
Brand: Wydawnictwo Nasza Wiedza
SKU: 9786209831744
Price: 10465.0 INR
Availability: InStock

by Bhaskar Nagilla

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ISBN13: 9786209831744
Binding: Paperback
Subject: N/A
Publisher: Wydawnictwo Nasza Wiedza
Publisher Imprint: Wydawnictwo Nasza Wiedza
Publication Date: March 27, 2026
Pages: 260
Original Price: USD 116.0
Language: Polish
Edition: N/A
Item Weight: 354 grams
BISAC Subject(s): Life Sciences / Zoology / General

About The Book

Cukrzycowy b�l neuropatyczny jest stanem niezwykle wyniszczającym i zazwyczaj trudnym do leczenia. Wyciąg metanolowy z Coccinia grandis zostal przebadany pod kątem dzialania przeciwb�lowego i przeciwzapalnego na modelu szczura z neuropatią cukrzycową wywolaną przez STZ. Ostra aktywnośc zapalna zostala zbadana za pomocą testu b�lowego Randalla. W nerwie kulszowym i m�zgu oznaczono koordynację nocyceptywną, nerwowo-mięśniową, parametry elektrofizjologiczne oraz mediatory stanu zapalnego, takie jak cyklooksygenaza i peroksydaza PG, kt�re przyczyniają się do b�lu neuropatycznego. Aktywnośc przeciwb�lową badano u szczur�w przy użyciu testu gorącej plyty i testu tail-flick. W nerwie kulszowym i m�zgu określono zmiany neurochemiczne, takie jak poziom glukozy, fruktozy, sorbitolu i zredukowanego glutationu. Po 3 tygodniach oznaczono r�wnież enzymy, takie jak heksokinaza, reduktaza aldozowa, dehydrogenaza sorbitolowa i dehydrogenaza glukozo-6-fosforanowa. Zbadano r�wnież zmiany histopatologiczne nerwu kulszowego i m�zgu. Przeanalizowano patologię wszystkich ważnych narząd�w, takich jak nerki, wątroba i jelita. Podsumowując, ekstrakt z liści Coccinia grandis wykazuje dzialanie przeciwzapalne i przeciwb�lowe, przeciwcukrzycowe oraz brak efektu toksycznego.

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