Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering

Name: Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering
Brand: Royal Society of Chemistry
SKU: 9781782629900
Price: 25538.0 INR
Availability: InStock

by Matthias J. Feige

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ISBN13: 9781782629900
Binding: Hardcover
Subject: N/A
Publisher: Royal Society of Chemistry
Publisher Imprint: Royal Society of Chemistry
Publication Date: July 31, 2018
Pages: 429
Original Price: GBP 179.0
Language: English
Edition: GLD
Item Weight: 817 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Disulphide bonds are important post-translational modifications of proteins that can covalently link cysteine residues far apart in the primary sequence of a protein. This can convey the needed stability to protein structures, but when incorrectly formed, these bonds interfere with folding or even cause aggregation, leading to disease. This book will begin with basic principles of disulphide bond formation. It then connects these to recent cell biological developments and ultimately the engineering of biomolecules and cells. This book will be an essential reference for advanced students and researchers in chemical biology and related fields who wish to gain the latest overview of this field.

About The Author

Matthias J. Feige studied biochemistry at the Swiss Federal Institute of Technology (ETH Zurich) and TUM. In 2009, he obtained his PhD in biochemistry under the supervision of Johannes Buchner at the TUM. As a postdoctoral fellow in the laboratory of Linda Hendershot at the St. Jude Children's Research Hospital, Memphis, TN, USA, he expanded his research towards cell biology and since 2015 heads the laboratory for cellular protein biochemistry at the TUM. Matthias J Feige's laboratory aims at understanding how cells control and maintain the integrity of their proteome. He is particularly interested in proteins of the secretory pathway - proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. Using an interdisciplinary approach from protein biochemistry to cell biology he analyses the machinery and mechanisms that monitor cellular protein biogenesis. By focusing on proteins of immunological and biomedical relevance, he seeks a molecular understanding of fundamental biological processes that at the same time may help in developing new approaches for protein engineering and human therapy.

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