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Pharmakokinetik Und Arzneistoffmetabolismus by H. Pelzer

Pharmakokinetik Und Arzneistoffmetabolismus

by H. Pelzer
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Book cover type: Paperback
  • ISBN13: 9783798505896
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Steinkopff
  • Publisher Imprint: Steinkopff
  • Publication Date:
  • Pages: 148
  • Original Price: USD 84.99
  • Language: German
  • Edition: N/A
  • Item Weight: 168 grams
  • BISAC Subject(s): Life Sciences / Biochemistry

Form und Inhalt des vorliegenden Taschenbuchs gehen auf eine Vorlesung zuriick, die in den Jahren 1972 bis 1975 an der Universitat Freiburg gehalten worden ist. Mit dem Titel "Meta- bolismus von Arzneimitteln" deckte diese Vorlesung den Teil des Pharmaziestudiums ab, der das Schicksal von Arzneistoffen im Organismus zum Inhalt hat. Das Hauptgewicht lag dabei auf der qualitativen Beschreibung der enzymatischen Umwandlungen von Arzneistoffen im Organismus und der schlieBlich mit dem Ham ausgeschiedenen Metaboliten. Pharmakokinetische Ge- sichtspunkte wurden nur beilaufig gestreift. Ais 3 Jahre spater das Vorlesungsmanuskript zu einem Band in der Reihe "Pharma- zie in Einzeldarstellungen" umgearbeitet werden sollte, ergab sich die Notwendigkeit einer besseren Verbindung zur allgemei- nen Pharmakologie, die gerade fUr Pharmazeuten von wachs en- der Bedeutung ist. Das war moglich durch eine inhalt1iche Erwei- terung des Kapitels Pharmakokinetik und den Verzicht auf die detaillierte Darstellung der Methoden zur Isolierung und Struk- turaufklarung von Arzneistoffmetaboliten aus biologischem Material. Einer gemeinsamen Darstellung von Kinetik und Metabolis- mus kommt zugute, daB die Biotransformation ohnehin als Teil- gebiet der Pharmakokinetik zu betrachten ist, da sich die Elimi- nation eines Arzneistoffs aus Metabolisierung und Ausschei- dung zusammensetzt und zudem pharmakologisch wirksame Metaboliten die Blutspiegel-Wirkungsrelation eines Arzneistof- fes maBgeblich beeinflussen konnen. Damit sind grundlegende Kenntnisse zum Metabolismus von Arzneistoffen nicht nur fUr Pharmazeuten von Bedeutung. Auch der praktizierende Arzt wird bei der rationalen Erstellung von Dosierungsplanen auf- grund pharmakokinetischer Parameter die metabolische Umwandlung des betreffenden Arzneimittels immer ins Auge fassen miissen.

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