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Benzodiazepine-Based Drug Discovery by Farzad Zamani

Benzodiazepine-Based Drug Discovery

by Farzad Zamani
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Book cover type: Paperback
  • ISBN13: 9780128245163
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Elsevier
  • Publisher Imprint: Elsevier
  • Publication Date:
  • Pages: 338
  • Original Price: USD 225.0
  • Language: English
  • Edition: N/A
  • Item Weight: 454 grams
  • BISAC Subject(s): Chemistry / Organic

Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry.

The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities.

Doustkhah, Esmail: - Esmail Doustkhah received his PhD in 2017 in the field of catalysis and organic chemistry. In his PhD, he received several awards and scholarships. Currently, he is a JSPS fellow at NIMS in the group of Professors Y. Yamauchi and Y. Ide. His research areas include silicate nanosheet, mesoporous materials, and titania nanostructures for (photo)(bio)catalysis.

Zamani, Farzad: - Farzad Zamani obtained his PhD from University of Wollongong (Australia) in 2019 under the supervision of Professor Stephen Pyne and Dr. Christopher Hyland. His research included development of transition metal-catalyzed cyclization reactions and heterocycle synthesis. Currently, he is a JSPS postdoctoral fellow in the group of Professor Takayoshi Suzuki at Osaka University working on investigation of small molecule inhibitors of RNA/epigenetic protein complexes in drug discovery.Farzad Zamani obtained his PhD from University of Wollongong (Australia) in 2019 under the supervision of Professor Stephen Pyne and Dr. Christopher Hyland. His research included development of transition metal-catalyzed cyclization reactions and heterocycle synthesis. Currently, he is a JSPS postdoctoral fellow in the group of Professor Takayoshi Suzuki at Osaka University working on investigation of small molecule inhibitors of RNA/epigenetic protein complexes in drug discovery.

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