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Blutersatz Durch Stromafreie Hämoglobinlösung: Ergebnisse Tierexperimenteller Untersuchungen by J. M. Unseld

Blutersatz Durch Stromafreie Hämoglobinlösung: Ergebnisse Tierexperimenteller Untersuchungen

by J. M. Unseld
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Book cover type: Paperback
  • ISBN13: 9783540069751
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 92
  • Original Price: EUR 51.39
  • Language: German
  • Edition: N/A
  • Item Weight: 159 grams
  • BISAC Subject(s): General

Durch die Untersuchungen von Herrn Dr. UNSELD wurde die alte faszinieren- de Idee, Sauerstofftragerlosungen ohne die bekannten Nachteile einer Voll- bluttransfusion infundieren zu konnen, wieder aufgegriffen. Experimentelle Untersuchungen mit Hamoglobinlosungen vor ca. 20 Jahren wur- den wegen der dabei entstehenden Nierenschadigungen zunachst wieder aufge- geben. 1967 gelang RABINER und Mitarbeitern der Nachweis, daE stromafreie Hamoglobinlosungen keine Nierenfunktionsstorungen verursachen. Die Haupt- vorteile einer solchen Hamoglobinlosung sind: expandierender Volumenersatz mit gleichzeitiger Erhohung der Sauerstofftransportkapazitat, Unabhangig- keit von Blutgruppeneigenschaften und keine tibertragung einer Transfusions- Hepatitis. Das Ziel der vorliegenden Arbeit war, die grundlegenden Moglich- keiten einer therapeutischen Verwendung von Hamoglobinlosungen als Bluter- satz zu erforschen. Dabei wurde vorwiegend die Wirkung auf die Nierenfunk- tion, den Kreislauf und die Sauerstoffaufnahme bzw.-abgabe sowohl beim nor- malen Tier als auch im hamorrhagischen Schock bei Zwergschweinen geprtift. Die ersten Ergebnisse mit der von BONHARD (Firma Biotest) hergestellten stromafreien Hamoglobinlosung mit einem Hb-Gehalt von etwa 6 g % ermutigten aufgrund der guten Nierenfunktion zu weiteren Untersuchungen tiber Kreislauf, Saure-Basen-Haushalt und Sauerstoffaufnahme. Zum Vergleich diente eine 5%- ige Human-Albuminlosung.

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