Enzyme: Teil a
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Als letzten Teil der 10. Auflage des Handbuches der physiologisch- und pathologisch- chemischen Analyse legen wir die Methoden der Enzymbestimmung vor. Während der Bearbeitung dieses Teils des Handbuches hat das Gebiet der Enzymologie eine stürmische Ausweitung erfahren, so da immer neue Enzyme und immer neue Gesichtspunkte mit- berücksichtigt werden mu ten. Der Wettlauf zwischen Forschung und Dokumentation ist für die letztere immer aussichtsloser geworden. Die Herausgeber müssen daher um Nachsicht bitten, wenn das vorliegende Werk nicht in allen Punkten den neuesten Stand der Wissenschaft wiedergibt. Das Interesse an den Enzymen ist in der neueren Zeit grö er geworden. Die Verwen- dung von Enzymreaktionen zur spezifischen analytischen Erfassung von Substanzen in komplexem biologischen Material, die Bestimmung von Enzymaktivitäten zu diagnosti- schen Zwecken durch den Kliniker, die Zurückführung pharmakologischer Wirkungen auf Beeinflussung von Enzymsystemen, um nur die wichtigsten Beispiele zu nennen, haben den Kreis der mit Enzymen arbeitenden Laboratorien wesentlich erweitert, aber auch die in diesem Werk zu berücksichtigenden Gesichtspunkte vermehrt. Entsprechend der Tradition und dem Titel des Handbuches ist auch in dem vorliegenden Enzymteil der Schwerpunkt der Darstellung auf der Analytik und der präparativen Gewinnung gelegen. Die Herausgeber hielten es aber für wünschenswert - zumal ein umfassenderes Werk über Enzymologie in deutscher Sprache gegenwärtig fehlt - auch noch andere, für den einen oder anderen mit Enzymen arbeitenden Forscher wichtige Gesichtspunkte zu be- rücksichtigen wie Vorkommen, Kinetik, Aktivatoren und Inhibitoren von Enzymen. Manche Enzyme sind heute käuflich beziehbar. In diesem Falle haben wir von einereingehenderen Schilderung der präparativen Darstellung Abstand genommen.
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