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Knochenersatzmittel by Johannes M. Rueger, A. Pannike

Knochenersatzmittel

by Johannes M. Rueger , A. Pannike
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Book cover type: Paperback
  • ISBN13: 9783540539391
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 301
  • Original Price: EUR 51.39
  • Language: German
  • Edition: N/A
  • Item Weight: 513 grams
  • BISAC Subject(s): Surgery / General

Die Suche nach einem geeigneten Knochenersatzmittel hat in den letzten Jahren zu der experimentellen, teilweise auch klinischen Erprobung der verschiedensten Substanzen und Substanzgemische (Composites) gef}hrt. Trotz intensiver Forschung konnte aber bis heute der Wirkmechanismus der "g{ngigen" Knochenersatzmittel nicht ausreichend erkl{rt und das Verhalten des Materials nach der Implantation mit gen}gender Zuverl{ssigkeitvorausgesagt werden. Unser vorherrschendes, mehr "morphologisches" Verst{ndnis der Knochenheilung m} te, aufgrund der Ergebnisse der Forschung in der Immunologie und der vielf{ltig entdeckten Mediatoren des Knochenanbaus und der Knochenresorption, durch eine eher kybernetische Vorsrtellung der Regulation der am Auf- und Abbau desKnochengewebes beteiligten Zellen und ihrer spezifischen Leistung und ihrer Produkte erweitert werden. Erst nach der Integration von Morphologie, Biochemie und Immunologie k-nnen die mechanistischen Vorstellungen }ber und die Anspr}che an ein Knochenersatzmittel revidiert werden. Ziel des vorliegenden Buches ist es, einen Anforderungskatalog der erw}nschten Leistungen von Knochenersatzmitteln zu erstellen, die als Knochenersatzmittel angebotenen Substanzen zu klassifizieren, ihre postulierten Wirkmechanismen zusammenfassend zu beschreiben, die bei der ]berpr}fung in einem standardisierten Tiermodell beobachteten tats{chlichen Aktivit{ten der verschiedensten Einzelsubstanzen und Composites kritisch - unter Ber}cksichtigung osteologischer, biomaterialkundlicher und immunologischer Ergebnisse - vergleichend zu interpretieren, um so einen realistischen Ausblick aufdie Entwicklung der Knochenersatzmittel in der Zukunft zu erm-glichen. Angesprochen sind Traumatologen, Orthop{den, Biomaterialkundler, plastische und Kieferchirurgen.

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