Myokarddurchblutung Und Stoffwechselparameter Im Arteriellen Blut Bei Hämodilutionsperfusion
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Die vorliegende Arbeit* entstand in den Jahren 1970-1972 wahrend meiner Tatigkeit an der Universitats-Klinik fUr Thorax- und Herz- GefaBchirurgie in Gottingen. Grundlage fUr die Untersuchung der Koronardurchblutung einschlieBlich des myocardialen Sauerstoff- verbrauchs war die von BRETSCHNEIDER und Mitarb. entwickelte Fremdgasmethode zur Organdurchblutungsmessung. Die untersuchungen wurden in Zusammenarbeit mit dem Institut fUr klinische Anaesthesie, dem Physiologischen Institut, Lehrstuhl I und dem Insulinlabor der Medizinischen Universitatsklinik in Got- tingen durchgefUhrt. Besonderer Dank gebUhrt Herrn Professor H.J. BRETSCHNEIDER fUr die Anregungen und wissenschaftliche Forderung meiner Untersuchungen und meinem chirurgischen Lehrer Herrn Professor J. KONCZ, der mir die Fertigstellung dieser Arbeit an seiner Klinik ermoglichte. Allen Kollegen und Mitarbeitern, insbesondere Herrn Professor H. SONNTAG, die mir bei den Untersuchungen behilflich waren, danke ich herzlich. D. Regensburger Gottingen, im August 1976 * Mit UnterstUtzung der Deutschen Forschungsgemeinschaft im Rah- men des SFB 89 - Kardiologie - Gottingen. INHALTSVERZEICHNIS I. Einleitung A. Entwicklung der extracorporalen Zirkulation .......... 1 B. Blutperfusion .....-..-.-..-.....--..------..-.....--. 3 c. VerdUnnungsperfusion .-...-......-.--................. 3 5 II. Probleme der Blutperfusion A. Komplikationen und Gefahren der MaschinenfUllung mit Fremdblut ..............-...........-...----.......... 5 B. Ethisch-religiose Probleme der Bluttransfusion ...-... 5 C. Schwierigkeiten der Blutbeschaffung, u.a. bei Noteingriffen mit der Herz-Lungen-Maschine -.........- 6 III. Fragestellung .....-.-....-..-..-....-.......-..--..---.. 7 IV. Krankengu t. . . . . . . . . . . . . . . - - . . - . . . . . . . - . . . .. . . 9 . - - . - - - . . . .
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