Pathobiochemie Der Entzündung: Merck Symposium Der Deutschen Gesellschaft Für Klinische Chemie Bonn, 5-7 Mai 1983
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Von den vier hier vorgestellten klinisch-chemischen KenngroBen eignet sich das saure aI-Glycoprotein niaht als Entzundungs- parameter im ZNS, wohl aber zur Erkennung geringer Storungen der Blut-Hirn-Schrankenfunktion. Laktoferrin und Lysozym, Bestandteile der Leukocyten, sind im Lumballiquor zur Erkennung und Differenzierung von Entzundungs- vorgangen im ZNS geeignet. Der hier vorgestellte immunnephelo- metrische Test ist fur Laktoferrin zu unempfindlich, fur Lysozym ausreichend empfindlich. Der Laktat-Test in Kornbination mit Leukocyten- und Erythro- cytenzahl ist am besten zur Erkennung und Differenzierung von akuten entzundlichen Erkrankungen des ZNS und seiner Haute geeignet. Wegen seiner schnellen Durchfuhrbarkeit kann der Test fur die Notfalldiagnostik empfohlen werden. Danksagung. Diese Arbeit wurde durch die Sachbeihilfe Kl 19314-1 der Deutschen Forschungsgemeinschaft ermoglicht. Literatur 1. KLEINE TO (1979) Liquor und Kopfschmerz. Ursachen und klinisch-chemische Diagnostik. Med Welt 30: 1029-1033, 1094-1097 2. OEHMICHEN M (1976) Cerebrospinal fluid cytology. Thieme, Stuttgart 3. KLEINE TO, BAERLOCHER K, NI'EDERER V, KELLER H, REUTTER F" TRITSCHLER W, BABLOCK W (1979) Diagnostische Bedeutung der Lactatbestimmung im Liquor bei Meningitis. Dtsch med Wschr 104: 553-557 4. KLEINE TO (1980) Neue Labormethoden fur die Liquordiagnostik. Thieme, Stuttgart 5. ALLEN RC, BIENVENU J, LAURENT P, SUSKIND RM (1982) Marker proteins in inflammation. Walter de Gruyter, Berlin 6. GAHMBERG CG, ANDERSSON LC (1978) J exp Med 148: 507-521 7. AVILA JL (1977) Acta Cient Venezolana 28: 115-126 8. GOLDSTEIN M (1976) Polymorphonuclear leukocyte lysosomes and immune tissue injury. Prog Allergy 20: 301-340 9.
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