• ISBN13: 9780306464478
• Binding: Hardcover
• Subject: N/A
• Publisher: Springer
• Publisher Imprint: Springer
• Publication Date: January 31, 2001
• Pages: 652
• Original Price: EUR 199.99
• Language: English
• Edition: 2002
• Item Weight: 1121 grams
• BISAC Subject(s): Biochemistry, Pharmacology, and Neurology

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3 M. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. membrane potential. ? pH gradient. Adapted from .