• ISBN13: 9780470015285
• Binding: Hardcover
• Subject: N/A
• Publisher: Wiley
• Publisher Imprint: Wiley
• Publication Date: September 1, 2007
• Pages: 373
• Original Price: USD 307.95
• Language: English
• Edition: N/A
• Item Weight: 1180 grams
• BISAC Subject(s): Research, Research & Methodology, and Life Sciences / Anatomy & Physiology

This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research.

Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates:

Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy.

Most chapters are written by teams of physicists and biologists, giving a balanced coherent description of each technique and its potential applications. 

Vasilis Ntziachristos. Massachusetts General Hospital, USA

Anne Leroy-Willig. Université Paris-Sud, France

Bertrand Tavitian. Unité d'Imagerie de l'Expression des Genes, CEA - SHFJ - INSERM ERITM, Orsay Cedex, France