Alternativa oral não invasiva às terapias farmacológicas com insulina para a diabetes

Name: Alternativa oral não invasiva às terapias farmacológicas com insulina para a diabetes
Brand: Edicoes Nosso Conhecimento
SKU: 9786209899119
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ISBN13: 9786209899119
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: April 1, 2026
Pages: 52
Original Price: USD 56.0
Language: Portuguese
Edition: N/A
Item Weight: 82 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

As alternativas de tratamento n�o invasivas para doen�as que v�o desde a diabetes at� � hipercolesterolemia est�o na vanguarda da investiga��o. Embora tenham sido investigadas muitas vias de administra��o de f�rmacos n�o invasivas, incluindo a oral, a bucal e a d�rmica, nenhuma via foi totalmente aprovada para uso em doentes pelos padr�es da Food and Drug Administration (FDA) como alternativa � atual administra��o de insulina dependente de agulhas. 10 12 Este livro centra-se em dois novos sistemas orais de administra��o de f�rmacos proteicos: fosfato de α-Zr(IV) (α-ZrP)-prote�na-i�es met�licos divalentes e fosfato de α-Zr(IV) (α-ZrP)-prote�na-albumina s�rica bovina catiionada (BSA). A glicose oxidase (GO) serve como prote�na modelo neste livro para alternativas n�o invasivas � redu��o do a��car no sangue em diab�ticos de tipo I e II. No entanto, em vez de encapsular a GO, um tratamento farmacol�gico oral para a diabetes, tamb�m podem ser encapsuladas prote�nas alternativas como tratamentos farmacol�gicos orais para doen�as como a hipercolesterolemia. Esta experi�ncia testa qual a vers�o ionizada da BSA (BSA nativa-TEPA (-25), BSA-TEPA (0), BSA-TEPA (-13), BSA-TEPA (+5) ou i�es met�licos divalentes (Mg (II), Ca (II) ou Ba (II)) intercalado no ZrP resulta na liga��o e liberta��o m�ximas de GO na regi�o intestinal.

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