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Amélioration des performances de certains médicaments hydrophobes by El-Mancy, Shereen

Amélioration des performances de certains médicaments hydrophobes

by Shereen El-Mancy
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Book cover type: Paperback
  • ISBN13: 9786200717788
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 212
  • Original Price: GBP 69.51
  • Language: French
  • Edition: N/A
  • Item Weight: 291 grams
  • BISAC Subject(s): Pharmacology

Dans le d�veloppement de formes posologiques pharmaceutiques, la formulation de m�dicaments hydrophobes repr�sente un d�fi majeur pour les formulateurs. Les formulations nanom�triques � base de lipides comptent parmi les candidats les plus prometteurs pour am�liorer la solubilit� des m�dicaments; les micro�mulsions (ME) et les syst�mes d'administration de m�dicaments auto-micro�mulsifiants (SMEDDS) ont fait l'objet d'une attention particuli�re. Cependant, les aspects li�s � la stabilit� des mol�cules m�dicamenteuses dans ces formulations n'ont pas �t� largement �tudi�s. Cet ouvrage pr�sente le d�veloppement et la formulation de deux m�dicaments hydrophobes (le k�toconazole (KTZ) et le glibenclamide (GBL)) dans des syst�mes � base de lipides afin d'am�liorer leurs performances en tenant compte des questions de stabilit�. Les ME topiques � base de KTZ ont montr� une activit� antifongique nettement am�lior�e, comme le prouvent leurs larges zones d'inhibition. De m�me, les MSEDDS � base de GBL ont montr� des profils de dissolution am�lior�s et l'�tude in vivo a refl�t� une activit� hypoglyc�miante nettement am�lior�e. Les tests de stabilit� des m�dicaments dans ces syst�mes � base de lipides ont �galement �t� inclus. Dans cet ouvrage, vous trouverez des arguments rationnels pour la s�lection des excipients, des suggestions de formulation, des tests de caract�risation, une �tude de compatibilit�, ainsi que des �tudes de stabilit� acc�l�r�e et � long terme pour ces formulations.

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