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Analisi molecolare del virus dell'epatite C nella popolazione marocchina by Ikram Brahim

Analisi molecolare del virus dell'epatite C nella popolazione marocchina

by Ikram Brahim
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Book cover type: Paperback
  • ISBN13: 9786209523113
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 80
  • Original Price: GBP 38.19
  • Language: Italian
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): Life Sciences / Biology

L'evoluzione del virus dell'epatite C (HCV) � un processo altamente dinamico. Esistono poche informazioni sull'epidemiologia molecolare degli isolati di HCV in Marocco, un'area nota per una prevalenza intermedia dell'infezione da HCV. Lo scopo di questo studio era determinare la distribuzione dei sottotipi dei ceppi di HCV in pazienti con infezione cronica da HCV in Marocco e stimare la prevalenza delle sostituzioni aminoacidiche nella regione core dell'HCV in pazienti marocchini non trattati in precedenza. In questo studio abbiamo incluso 185 pazienti positivi all'anti-HCV. L'identificazione del sottotipo di HCV � stata effettuata rispettivamente mediante sequenziamento delle regioni 5'UTR, core e NS5B. La storia demografica dell'HCV � stata dedotta utilizzando un'analisi bayesiana con catena di Markov Monte Carlo. L'analisi filogenetica basata sulla regione NS5B ha rivelato che il sottotipo 1b (75,2%) era il pi� comune, seguito dal sottotipo 2i (19,1%). Il sottotipo 1b dell'HCV aveva una prevalenza ancora pi� elevata nel carcinoma epatocellulare. Utilizzando un approccio bayesiano, la data media di comparsa dell'antenato comune pi� recente � stata stimata nel 1910 per l'HCV-1b e nel 1854 per l'HCV-2i. Sulla base della regione core, sono state rilevate mutazioni a R70Q o L91M in pi� di un quarto dei pazienti infetti da HCV-1b.

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