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ANALYSE DES VACCINS D'ARNm by Suman Sharma

ANALYSE DES VACCINS D'ARNm

by Suman Sharma , Pragya Sharma , Prerna Gupta
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Book cover type: Paperback
  • ISBN13: 9786207892129
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 116
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 182 grams
  • BISAC Subject(s): Pharmacology

L'ARN messager est devenu le centre de la recherche en médecine moléculaire, car il s'agit d'une molécule non toxique qui permet l'expression transitoire de la caprotéine dans pratiquement tous les types de cellules, y compris les cellules dendritiques. Les principes qui sous-tendent les vaccins à base d'acides nucléiques sont ancrés dans le dogme central de Watson et Crick: l'ADN est transcrit en ARNm, qui est à son tour traduit en protéines. L'ARNm est produit synthétiquement et formulé en vaccins. Les ARNm sont traduits en antigènes correspondants après avoir été inoculés dans les cellules hôtes, imitant ainsi l'immunité humorale et l'immunité cellulaire semblables à celles d'une infection virale. Les vaccins ARNm optimisés doivent répondre à l'exigence selon laquelle l'immunité innée est pleinement activée pour déclencher l'immunité adaptative. Le premier vaccin candidat lancé dans les essais cliniques est un vaccin ARNm délivré par des nanoparticules lipidiques. Cet avantage détermine la rapidité des réponses immunitaires après l'administration de l'ARNm. Le vaccin ARNm est largement utilisé pour les maladies infectieuses.

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