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ANALYSE VON mRNA-VAKZINEN by Sharma, Suman

ANALYSE VON mRNA-VAKZINEN

by Suman Sharma , Pragya Sharma , Prerna Gupta
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Book cover type: Paperback
  • ISBN13: 9786207892051
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 116
  • Original Price: GBP 51.0
  • Language: German
  • Edition: N/A
  • Item Weight: 182 grams
  • BISAC Subject(s): Pharmacology

Die Boten-RNA rückte in den Mittelpunkt der Forschung in der Molekularmedizin, da sie ein ungiftiges Molekül ist, das eine vorübergehende Kaproteinexpression in praktisch allen Zelltypen, einschlie lich dendritischer Zellen, ermöglicht. Die Grundlagen für Nukleinsäureimpfstoffe beruhen auf dem zentralen Dogma von Watson und Crick, dass DNA in mRNA umgeschrieben wird, die wiederum in Protein übersetzt wird. Die mRNA wird synthetisch hergestellt und zu Impfstoffen formuliert. Bei der mRNA-Impfstoffsynthese werden die mRNA-Transkripte durch Hochleistungs-Flüssigkeitschromatographie (HPLC) gereinigt, um Verunreinigungen und Reaktanten zu entfernen. Die mRNAs werden in entsprechende Antigene übersetzt, nachdem sie in die Wirtszellen geimpft wurden, wodurch eine virusinfektionsähnliche humorale Immunität und zelluläre Immunität imitiert wird. Mit Hilfe von mRNA-Impfstoffen kann die Antigenreaktivität erhöht werden. Die optimierten mRNA-Impfstoffe sollten die Voraussetzung erfüllen, dass die angeborene Immunität vollständig aktiviert wird, um die adaptive Immunität zu initiieren. Der erste Impfstoffkandidat, der in die klinische Erprobung gebracht wurde, ist ein mRNA-Impfstoff, der über Lipid-Nanopartikel verabreicht wird. Dieser Vorteil ist ausschlaggebend für die schnelle Immunantwort nach der Verabreichung der mRNA. MRNA-Impfstoff für Infektionskrankheiten weit verbreitet.

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