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Angewandte Klinische Pharmakologie: Phase-I-Prüfungen by P. W. Lücker, W. Rindt, M. Eldon

Angewandte Klinische Pharmakologie: Phase-I-Prüfungen

by P. W. Lücker , W. Rindt , M. Eldon
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Book cover type: Paperback
  • ISBN13: 9783540113539
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 150
  • Original Price: GBP 46.99
  • Language: German
  • Edition: Softcover Repri
  • Item Weight: 177 grams
  • BISAC Subject(s): Pharmacology

Unsere Arzneimittel werden immer differenzierter und spezifischer in ihrer Wirkung. Die griindliche, vertiefte Priifung neuer Substanzen vor der ersten therapeu tischen Anwendung ist ein dringendes Erfordernis, urn ScMden von spateren Patienten abzuwenden. Die relativ junge Disziplin "klinische Pharmakologie" hat sich dieser Aufgabe in verstarktem MaBe angenommen. Den Grundstein legte bereits Paul Martini im Jahre 1947 mit seiner "Methodenlehre der therapeutisch-klinischen Forschung." In der Einfuhrung ist zu lesen "Nur einer Therapieform, die einer zureichen den klinischen Priifung unterzogen worden ist, und die diese bestanden hat, kann zuerkannt werden, daB sie eine rationale und reale Therapie im engeren Sinne sei, d. h. daB sie in vo11em Umfang den Anforderungen entspricht, die die menschliche Vernunft und Ethik in Situationen ste11en miissen, in denen es urn Gesundheit und Lehre geht." Dieser Satz ist 35 Jahre alt und hat bis heute an Bedeutung nichts verloren. Seinen Niederschlag fand er in der Deklaration von Helsinki sowie schluBend lich im neuen Arzneimittelgesetz yom 24. August 1976. Weltweit wird die Arzneimittelpriifung in vier Phasen unterteilt. In der Phase I werden Untersuchungen an gesunden Versuchspersonen durchgefuhrt."

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