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Anthropologie moleculaire et epidemiologie by Collectif

Anthropologie moleculaire et epidemiologie

by Collectif
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Book cover type: Paperback
  • ISBN13: 9786131532290
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 268
  • Original Price: GBP 66.0
  • Language: French
  • Edition: N/A
  • Item Weight: 395 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

En vingt ans, l''ADN mitochondrial (ADNmt) s''est impos� comme un acteur majeur de l''anthropologie mol�culaire. L''�tude des polymorphismes de l''ADNmt a permis d''une part de r�v�ler la proximit� de l''homme avec le chimpanz� et l''Homme de Neandertal et d''autre part de d�montrer l''origine africaine de l''Homme moderne.ependant, durant la m�me p�riode, des mutations pathog�nes de l''ADNmt ont �t� associ�es � des nombreuses maladies telles que des myopathies. Nous avons �tudi� si les polymorphismes de l''ADNmt pouvaient influencer les pathologies caus�es par les mutations pathogenes. Par la suite, nous avons �tudi� l''homog�n�it� du taux de mutation des lign�es europ�ennes de l''ADNmt. Au terme de ces travaux nous proposons que (i) certaines lign�es mitochondriales (haplogroupe J) ont accumul� des polymorphismes pouvant influencer l''expression des pathologies et ayant pu jouer un r�le dans l''adaptation au climat des populations humaines. (ii) la phylog�nie mitochondriale humaine pr�sente un rythme de mutation rapide et stable, mais pouvant n�anmoins pr�senter des irr�gularit�s de tempo sur certaines positions (hot- spot) ou certaines lign�es (R0).

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