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Apoptom: séquence pro-apoptotique des flavivirus by Catteau-A

Apoptom: séquence pro-apoptotique des flavivirus

by Catteau-A
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Book cover type: Paperback
  • ISBN13: 9786131570353
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 280
  • Original Price: GBP 70.0
  • Language: French
  • Edition: N/A
  • Item Weight: 413 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Les flavivirus sont responsables de maladies humaines caractérisées par une fièvre non différenciée pouvant évoluer vers un syndrome hémorragique (fièvre jaune, dengue) ou méningo- encéphalitique (encéphalite japonaise, fièvre du Nil occidental). Une des conséquences de l'infection virale est l'induction de la mort cellulaire par apoptose. Nous avons identifié une séquence de neuf acides aminés de la protéine M, désignée ApoptoM, comme séquence virale pro-apoptotique. Le résidu M- 36 est unique par sa capacité à moduler l'activité de mort d'ApoptoM. La séquence ApoptoM manifeste son potentiel pro-apoptotique lorsqu'elle est localisée dans un compartiment post-golgien. L'apoptose induite par ApoptoM engage une signalisation dépendante des mitochondries et nécessite l'activation des caspases. Notre étude souligne l'importance de la contribution de la protéine structurale M dans la pathogénicité des flavivirus.

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