As alterações na acetilação das proteínas SR podem afetar o splicing alternativo?

Name: As alterações na acetilação das proteínas SR podem afetar o splicing alternativo?
Brand: Edicoes Nosso Conhecimento
SKU: 9786630087253
Price: 5442.0 INR
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ISBN13: 9786630087253
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: May 18, 2026
Pages: 64
Original Price: GBP 43.0
Language: Portuguese
Edition: N/A
Item Weight: 100 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

O fen�tipo e a fun��o celular s�o determinados pelo proteoma celular. No seio do proteoma celular, existem processos com potencial para alterar significativamente a composi��o do proteoma. Um desses processos � denominado splicing alternativo. O splicing consiste na remo��o de intr�es de uma sequ�ncia de pr�-mRNA, sendo que as sequ�ncias de pr�-mRNA restantes, denominadas ex�es, s�o combinadas. O splicing alternativo modifica a combina��o de intr�es e ex�es e pode formar novos produtos a partir do diferente arranjo das sequ�ncias codificantes. A desregula��o do splicing alternativo tem sido documentada em muitas doen�as humanas. A regula��o do splicing alternativo envolve uma rede complexa de prote�nas e ARN. As prote�nas de repeti��o serina-arginina (SR) s�o uma fam�lia conhecida de prote�nas reguladoras que se ligam dentro dos ex�es para promover a inclus�o dos ex�es na transcri��o madura do mRNA. A atividade das prote�nas SR � regulada por modifica��es p�s-traducionais, fosforila��o e acetila��o. O estudo em quest�o prop�e um poss�vel mecanismo de como a acetila��o das prote�nas SR pode alterar o splicing alternativo. Este livro dever� ser �til para qualquer pessoa interessada na regula��o do splicing alternativo e nas prote�nas SR.

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