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Avaliação do Estriol by Aakifa Ahmad, Naushad Alam

Avaliação do Estriol

by Aakifa Ahmad , Naushad Alam
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Book cover type: Paperback
  • ISBN13: 9786209500909
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 84
  • Original Price: GBP 38.19
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 123 grams
  • BISAC Subject(s): Pharmacology

O efeito do estriol, o terceiro estrog�nio, foi avaliado quanto ao seu efeito no modelo de epileptog�nese de pentilenotetrazol (PTZ) em camundongos, seguido de avalia��o nas altera��es induzidas por kindling nas fun��es cognitivas e motoras. O kindling foi induzido por tratamento uma vez a cada 2 dias com PTZ (25 mg/kg, i.p.) durante 5 semanas. A gravidade das convuls�es durante a indu��o da igni��o e a incid�ncia percentual de animais inflamados no final de 5 semanas foram registradas. A fun��o motora foi avaliada por meio de um medidor de for�a de preens�o enquanto a mem�ria espacial foi avaliada em um labirinto cruzado. O estriol (0,005 e 0,01 mg/kg i.p.) reduziu o tempo de indu��o do kindling de 5 semanas para 3 e 2 semanas para camundongos machos e f�meas, respectivamente, e aumentou a incid�ncia percentual de convuls�es. O clomifeno (0,9 mg/kg i.p.) atrasou o desenvolvimento de kindling e produziu efeitos anticonvulsivantes. Tamb�m reverteu parcialmente os efeitos pr�-convulsivantes do estriol. No teste de for�a de preens�o e no comportamento de altern�ncia espont�nea, foi observado um decl�nio significativo em camundongos inflamados, que foi ainda reduzido pelo pr�-tratamento com estriol.

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