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Bacterioterapia de doenças alérgicas by Mahmoud Zaky

Bacterioterapia de doenças alérgicas

by Mahmoud Zaky , Nada Mohamed
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Book cover type: Paperback
  • ISBN13: 9786208931438
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 80
  • Original Price: GBP 31.23
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Estudos epidemiol�gicos recentes e ensaios cl�nicos sugerem um poss�vel papel de certas estirpes de bact�rias l�cticas (LAB) na preven��o de doen�as al�rgicas. Neste estudo, o nosso objetivo foi avaliar o potencial imunomodulador de duas estirpes de LAB, Lactococcus lactis e Lactobacillus plantarum, para a profilaxia e terapia de respostas imunit�rias al�rgicas. Ambas as estirpes LAB induziram n�veis elevados de IL-12 e IFN em culturas de c�lulas de ba�o murino virgens. A coaplica��o intranasal com Bet v 1 recombinante, o principal al�rgeno do p�len de b�tula, antes ou ap�s a sensibiliza��o al�rgica, levou a n�veis aumentados de anticorpos IgG2a espec�ficos do al�rgeno e � produ��o de IFN in vitro, indicando uma mudan�a para respostas Th1. A imunomodula��o bem-sucedida pelo pr�-tratamento da mucosa foi ainda demonstrada pela supress�o da degranula��o de bas�filos induzida por al�rgenos. Conclu�mos que estas estirpes de LAB em combina��o com um al�rgeno podem ser candidatos promissores para a vacina��o mucosa contra a alergia do tipo I.

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