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Bactériothérapie des maladies allergiques by Mahmoud Zaky

Bactériothérapie des maladies allergiques

by Mahmoud Zaky , Nada Mohamed
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Book cover type: Paperback
  • ISBN13: 9786208931407
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 84
  • Original Price: GBP 31.23
  • Language: French
  • Edition: N/A
  • Item Weight: 123 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Des �tudes �pid�miologiques et des essais cliniques r�cents sugg�rent que certaines souches de bact�ries lactiques (LAB) pourraient jouer un r�le dans la pr�vention des maladies allergiques. Dans cette �tude, nous avons cherch� � �valuer le potentiel immunomodulateur de deux souches de LAB, Lactococcus lactis et Lactobacillus plantarum, dans la prophylaxie et le traitement des r�ponses immunitaires allergiques. Les deux souches de LAB ont induit des taux �lev�s d'IL-12 et d'IFN dans des cultures de cellules spl�niques murines na�ves. L'application intranasale concomitante de Bet v 1 recombinant, le principal allerg�ne du pollen de bouleau, avant ou apr�s la sensibilisation allergique, a entra�n� une augmentation des taux d'anticorps IgG2a sp�cifiques de l'allerg�ne et de la production d'IFN in vitro, indiquant un glissement vers des r�ponses Th1. L'efficacit� de l'immunomodulation par le pr�traitement muqueux a �t� confirm�e par la suppression de la d�granulation des basophiles induite par les allerg�nes. Nous concluons que ces souches de LAB, en association avec un allerg�ne, pourraient constituer des candidats prometteurs pour la vaccination muqueuse contre les allergies de type I.

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