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Bakterientherapie bei allergischen Erkrankungen by Mahmoud Zaky

Bakterientherapie bei allergischen Erkrankungen

by Mahmoud Zaky , Nada Mohamed
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Book cover type: Paperback
  • ISBN13: 9786208931384
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 84
  • Original Price: GBP 31.23
  • Language: German
  • Edition: N/A
  • Item Weight: 123 grams
  • BISAC Subject(s): Life Sciences / Microbiology

J�ngste epidemiologische Studien und klinische Versuche deuten auf eine m�gliche Rolle bestimmter Milchs�urebakterienst�mme (LAB) bei der Vorbeugung von allergischen Erkrankungen hin. In dieser Studie haben wir das immunmodulatorische Potenzial von zwei LAB-St�mmen, Lactococcuslactis und Lactobacillus plantarum, f�r die Prophylaxe und Therapie von allergischen Immunreaktionen untersucht. Beide LAB-St�mme - induzierten in naiven Milzzellkulturen von M�usen hohe Mengen an IL-12 und IFN. Die gleichzeitige intranasale Verabreichung von rekombinantem Bet v 1, dem Hauptallergen der Birkenpollen, vor oder nach einer allergischen Sensibilisierung f�hrte zu einer Erh�hung der allergenspezifischen IgG2a-Antik�rper und der In-vitro-IFN-Produktion, was auf eine Verschiebung hin zu Th1-Reaktionen hinweist. Die erfolgreiche Immunmodulation durch die mukosale Vorbehandlung wurde au erdem durch die Unterdr�ckung der Allergen-induzierten basophilen Degranulation nachgewiesen. Wir kommen zu dem Schluss, dass diese LAB-St�mme in Kombination mit einem Allergen vielversprechende Kandidaten f�r eine mukosale Impfung gegen Typ-I-Allergien sein k�nnten.

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