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Bakterioterapia chorób alergicznych by Mahmoud Zaky

Bakterioterapia chorób alergicznych

by Mahmoud Zaky , Nada Mohamed
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Book cover type: Paperback
  • ISBN13: 9786208931421
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Publication Date:
  • Pages: 80
  • Original Price: GBP 31.23
  • Language: Polish
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Najnowsze badania epidemiologiczne i kliniczne sugerują, że niekt�re szczepy bakterii kwasu mlekowego (LAB) mogą odgrywac rolę w profilaktyce chor�b alergicznych. W niniejszym badaniu postawiono sobie za cel ocenę potencjalu immunomodulującego dw�ch szczep�w LAB, Lactococcus lactis i Lactobacillus plantarum, w profilaktyce i terapii alergicznych reakcji immunologicznych. Oba szczepy LAB wywolywaly wysokie poziomy IL-12 i IFN w hodowlach naiwnych kom�rek śledziony myszy. Wewnątrznosowe wsp�lpodanie rekombinowanego Bet v 1, gl�wnego alergenu pylku brzozy, przed lub po uczuleniu alergicznym, prowadzilo do zwiększenia poziomu przeciwcial IgG2a specyficznych dla alergenu oraz produkcji IFN in vitro, co wskazuje na przejście w kierunku odpowiedzi Th1. Skuteczna immunomodulacja poprzez wstępne leczenie blony śluzowej zostala dodatkowo potwierdzona przez zahamowanie degranulacji bazofil�w wywolanej alergenem. Stwierdzamy, że te szczepy LAB w polączeniu z alergenem mogą byc obiecującymi kandydatami do szczepień śluz�wkowych przeciwko alergii typu I.

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