Bases biológicas e implicações clínicas da metformina

Name: Bases biológicas e implicações clínicas da metformina
Brand: Edicoes Nosso Conhecimento
SKU: 9786209744235
Price: 5036.0 INR
Availability: InStock

by Aniket Jadhav

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ISBN13: 9786209744235
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: March 20, 2026
Pages: 84
Original Price: USD 56.0
Language: Portuguese
Edition: N/A
Item Weight: 123 grams
BISAC Subject(s): Dentistry / General

About The Book

A metformina surgiu recentemente como uma mol�cula biologicamente ativa promissora na endodontia, com potencial utiliza��o como medicamento intracanal. Para al�m do seu efeito sist�mico de redu��o da glicose, a metformina ativa a via da AMPK, levando � modula��o da inflama��o, � redu��o de citocinas pr�-inflamat�rias, como a IL-6 e o TNF-α, e � inibi��o da reabsor��o �ssea mediada por osteoclastos. Estas ac��es contribuem para o aumento da diferencia��o osteobl�stica e da mineraliza��o, apoiando assim a cicatriza��o do osso periapical. Estudos experimentais sugerem que a metformina pode promover a prolifera��o e a diferencia��o das c�lulas estaminais da polpa dent�ria e das c�lulas estaminais da papila apical, indicando um papel potencial nos procedimentos endod�nticos regenerativos. Al�m disso, apresenta uma atividade antimicrobiana moderada contra agentes patog�nicos endod�nticos comuns, ao mesmo tempo que demonstra uma biocompatibilidade favor�vel em concentra��es controladas. Em compara��o com os medicamentos convencionais, como o hidr�xido de c�lcio, a metformina oferece uma abordagem biol�gica centrada na regenera��o dos tecidos e n�o apenas na desinfe��o baseada na alcalinidade.

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