Bases biologiques et implications cliniques de la metformine

Name: Bases biologiques et implications cliniques de la metformine
Brand: Editions Notre Savoir
SKU: 9786209648120
Price: 5127.0 INR
Availability: InStock

by Aniket Jadhav

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ISBN13: 9786209648120
Binding: Paperback
Subject: N/A
Publisher: Editions Notre Savoir
Publisher Imprint: Editions Notre Savoir
Publication Date: March 24, 2026
Pages: 88
Original Price: USD 57.0
Language: French
Edition: N/A
Item Weight: 127 grams
BISAC Subject(s): Dentistry / General

About The Book

La metformine est r�cemment apparue comme une mol�cule biologiquement active prometteuse en endodontie, avec une utilisation potentielle en tant que m�dicament intracanalaire. Au-del� de son effet hypoglyc�miant syst�mique, la metformine active la voie AMPK, ce qui entra�ne une modulation de l'inflammation, une r�duction des cytokines pro-inflammatoires telles que IL-6 et TNF-α, et une inhibition de la r�sorption osseuse m�di�e par les ost�oclastes. Ces actions contribuent � l'am�lioration de la diff�renciation ost�oblastique et de la min�ralisation, favorisant ainsi la gu�rison de l'os p�riapical. Des �tudes exp�rimentales sugg�rent que la metformine peut favoriser la prolif�ration et la diff�renciation des cellules souches de la pulpe dentaire et des cellules souches de la papille apicale, ce qui indique un r�le potentiel dans les proc�dures endodontiques r�g�n�ratives. En outre, elle pr�sente une activit� antimicrobienne mod�r�e contre les pathog�nes endodontiques courants, tout en faisant preuve d'une biocompatibilit� favorable � des concentrations contr�l�es. Par rapport aux m�dicaments conventionnels tels que l'hydroxyde de calcium, la metformine offre une approche biologique ax�e sur la r�g�n�ration des tissus plut�t que sur une d�sinfection bas�e uniquement sur l'alcalinit�.

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