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Biogénese mitocondrial na patogénese da endometriose by Beeram Hima Bindu

Biogénese mitocondrial na patogénese da endometriose

by Beeram Hima Bindu , Prof Manjula Bhanoori
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Book cover type: Paperback
  • ISBN13: 9786207729661
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 88
  • Original Price: GBP 68.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 141 grams
  • BISAC Subject(s): Life Sciences / Biology

A endometriose é uma doença dependente de estrogénio que apresenta um crescimento anormal de tecido semelhante ao endométrio fora da cavidade uterina nas mulheres em idade reprodutiva. Estima-se que afecte 5-10% das mulheres em idade reprodutiva em todo o mundo. A biogénese mitocondrial deficiente e a resposta inflamatória induzida pelo stress oxidativo na cavidade pélvica têm sido implicadas na patogénese da endometriose. Sendo uma doença inflamatória e associada ao metabolismo energético, uma vez que os genes TFAM, PGC-1α e VDR estão envolvidos na manutenção da integridade e do número de cópias do ADN mitocondrial, a análise dos polimorfismos dos genes TFAM, PGC-1α e VDR em relação ao número de cópias do ADN mitocondrial permitirá compreender melhor a fisiopatologia da endometriose.

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