Biologiczne podstawy i kliniczne implikacje stosowania metforminy

Name: Biologiczne podstawy i kliniczne implikacje stosowania metforminy
Brand: Wydawnictwo Nasza Wiedza
SKU: 9786209710759
Price: 5037.0 INR
Availability: InStock

by Aniket Jadhav

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ISBN13: 9786209710759
Binding: Paperback
Subject: N/A
Publisher: Wydawnictwo Nasza Wiedza
Publisher Imprint: Wydawnictwo Nasza Wiedza
Publication Date: March 20, 2026
Pages: 88
Original Price: USD 56.0
Language: Polish
Edition: N/A
Item Weight: 127 grams
BISAC Subject(s): Dentistry / General

About The Book

Metformina pojawila się ostatnio jako obiecująca biologicznie aktywna cząsteczka w endodoncji z potencjalnym zastosowaniem jako lek wewnątrzkanalowy. Opr�cz og�lnoustrojowego dzialania obniżającego poziom glukozy, metformina aktywuje szlak AMPK, prowadząc do modulacji stanu zapalnego, redukcji cytokin prozapalnych, takich jak IL-6 i TNF-α, oraz hamowania resorpcji kości za pośrednictwem osteoklast�w. Dzialania te przyczyniają się do zwiększonego r�żnicowania osteoblast�w i mineralizacji, wspomagając w ten spos�b gojenie kości okolowierzcholkowej. Badania eksperymentalne sugerują, że metformina może promowac proliferację i r�żnicowanie kom�rek macierzystych miazgi zębowej i kom�rek macierzystych brodawki wierzcholkowej, wskazując na potencjalną rolę w regeneracyjnych procedurach endodontycznych. Ponadto wykazuje umiarkowaną aktywnośc przeciwdrobnoustrojową przeciwko powszechnym patogenom endodontycznym, wykazując jednocześnie korzystną biokompatybilnośc w kontrolowanych stężeniach. W por�wnaniu z konwencjonalnymi lekami, takimi jak wodorotlenek wapnia, metformina oferuje biologicznie napędzane podejście skoncentrowane na regeneracji tkanek, a nie wylącznie dezynfekcji opartej na zasadowości.

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