Biologische Grundlagen und klinische Auswirkungen von Metformin

Name: Biologische Grundlagen und klinische Auswirkungen von Metformin
Brand: Verlag Unser Wissen
SKU: 9786209777295
Price: 6910.0 INR
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by Aniket Jadhav

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ISBN13: 9786209777295
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: March 20, 2026
Pages: 88
Original Price: USD 77.0
Language: German
Edition: N/A
Item Weight: 127 grams
BISAC Subject(s): Dentistry / General

About The Book

Metformin hat sich in j�ngster Zeit als vielversprechendes biologisch aktives Molek�l in der Endodontie erwiesen, das als intrakanales Medikament eingesetzt werden k�nnte. Neben seiner systemischen glukosesenkenden Wirkung aktiviert Metformin den AMPK-Signalweg, was zu einer Modulation der Entz�ndung, einer Verringerung proinflammatorischer Zytokine wie IL-6 und TNF-α und einer Hemmung der osteoklastenvermittelten Knochenresorption f�hrt. Diese Wirkungen tragen zu einer verst�rkten osteoblastischen Differenzierung und Mineralisierung bei und unterst�tzen so die periapikale Knochenheilung. Experimentelle Studien deuten darauf hin, dass Metformin die Proliferation und Differenzierung von Zahnmarkstammzellen und Stammzellen der apikalen Papille f�rdern kann, was auf eine m�gliche Rolle bei regenerativen endodontischen Verfahren hindeutet. Dar�ber hinaus zeigt es eine m� ige antimikrobielle Aktivit�t gegen g�ngige endodontische Pathogene und weist bei kontrollierten Konzentrationen eine g�nstige Biokompatibilit�t auf. Im Vergleich zu konventionellen Medikamenten wie Calciumhydroxid bietet Metformin einen biologisch orientierten Ansatz, der sich auf die Geweberegeneration und nicht nur auf die alkalische Desinfektion konzentriert.

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