Biopharmaceuticals: Biochemistry and Biotechnology
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Updated all-in-one guide to understanding the science, development and manufacture of bio-based therapeutics Biopharmaceuticals: Biochemistry and Biotechnology is a unique resource on biopharmaceuticals that serves as a comprehensive introduction to both the biopharmaceutical industry and its role within the global pharmaceutical industry. This new edition incorporates all major advances from the past 20 years, including the development of biosimilars, bispecific and other engineered antibody formats, engineered cell-based therapies, RNA-based vaccines, and genome editing techniques. Case studies and application examples demonstrate the entire value chain, from development to approval and manufacturing of all types of biopharmaceuticals, covering antibodies (mAbs), cytokines, nucleic acid therapeutics as well as cell-based and other biotherapeutics. Written by an accomplished instructor and textbook writer who has been working with small and large biotech companies for more than 25 years, Biopharmaceuticals: Biochemistry and Biotechnology covers: Protein structure (covering protein folding, stability, engineering and structure prediction, post-translational modifications) and recombinant productionDiscovery, development and biopharmaceutical regulationmAb-based therapeutics and vaccinesCytokines and growth factors, including interferons, interleukins, haematopoietic growth factors, and colony stimulating factors (CSFs)Recombinant blood products and therapeutic enzymes, covering clotting disorders, anticoagulants, thrombolytic agents, and enzymes of therapeutic valueHormones, including insulins, GLP-1 related products, human growth hormone and gonadotropinsProduct manufacture (upstream and downstream processing) and analysis, covering API characterization, purity and potency determinations, analytical methodologies, protein content, and contaminant testing Delivering comprehensive coverage of the field, Biopharmaceuticals: Biochemistry and Biotechnology is an essential reference for students and professionals in biotechnology, medical biochemistry, medicinal chemistry, and pharmaceutical technology.
Gary Walsh is Chair of Industrial Biotechnology at the University of Limerick, Ireland. He has direct industrial experience within the pharmaceutical and diagnostic industries, as well as extensive teaching and research interests in the pharmaceutical and biotechnology arena.
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