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Bismuth-Ethanedithiol: A Potential Drug to Treat Biofilm Infections of Medical Devices Produced by Staphylococcus Epidermidis and Proteus Mirabilis by Jithendra Gunawardana

Bismuth-Ethanedithiol: A Potential Drug to Treat Biofilm Infections of Medical Devices Produced by Staphylococcus Epidermidis and Proteus Mirabilis

by Jithendra Gunawardana
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Book cover type: Paperback
  • ISBN13: 9781599423043
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Dissertation.com
  • Publisher Imprint: Dissertation.com
  • Publication Date:
  • Pages: 98
  • Original Price: GBP 19.95
  • Language: English
  • Edition: N/A
  • Item Weight: 191 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Staphylococcus epidermidis is the leading cause of hospital-acquired infections associated with implanted medical devices. Likewise, Proteus mirabilis is one of the leading causes of nosocomial Urinary Tract Infections (UTIs) and is associated with urinary catheter blockage. Both organisms produce biofilms, which make them less susceptible to antibiotics. Therefore, these infections are often notoriously difficult to treat and in many cases lead to complications. Preventing biofilm formation or killing a pre-existing biofilm would be useful solutions since biofilm formation is a phenomenon commonly observed in these organsims. This study investigated the in vitro efficacy of Bismuth-ethanedithiol (BisEDT) against biofilms produced by P. mirabilis and S. epidermidis. Anti-biofilm activity of BisEDT was evaluated in terms of inhibiting/preventing biofilm formation and eradicating/killing pre-formed biofilm produced by single species S. epidermidis and P. mirabilis.

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