Calciumantagonisten Der Zweiten Generation
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"Schon wieder so ein verdammtes, dickes, spie iges Buch! Immer kritzeln, kritzeln, kritzeln, nicht wahr, Mr. Gibbon!" Aus den Literarischen Memoiren von Herzog Wilhelm von Gloucester, 1743-1805 Bei jedem Buch ist das Vorwort wahrscheinlich das Schwierigste. Nicht nur weil es am Beginn einer Übung im Schreiben und im folgerichtigen Denken steht, sondern weil der Leser an dieser Stelle eine eindeutige Erklärung dafür erwarten kann, warum das Buch überhaupt geschrie- ben wurde und warum manche Themen besprochen, andere hingegen weggelassen wurden. Mancher Leser wird sich vielleicht keine Gedanken darüber machen, warum der eine oder andere Punkt nicht erwähnt wurde; er wird sich vielmehr fragen, warum schon wieder ein Buch über Calciumantagoni- sten erscheint. Ich glaube aber, es kann mit Fug und Recht behauptet werden, da auf diesem Gebiet in der letzten Zeit zumindest drei Ent- wicklungen zu verzeichnen waren, welche die Veröffentlichung eines neuen Buches zu diesem Thema unbedingt gerechtfertigt erscheinen las- sen: I. Wir wissen heute mehr über die chemische Struktur, die Wirkungs- weise und den Aufbau der spannungsempfindlichen, auf Calcium- antagonisten ansprechenden Calcium-Kanäle und ihre für Calcium- antagonisten spezifischen Bindungsstellen. II. Die Anwendungsmöglichkeiten von Calciumantagonisten zur Be- handlung einer Vielfalt von Erkrankungen wie zerebrale Ischämie, Atherosklerose, "leichte" ischämische Herzkrankheit, Linksherz- hypertrophie, beeinträchtigte ventrikuläre Relaxation und Hyper- tonie, um nur einige zu nennen, können heute besser beurteilt wer- den. 111. Eine zweite Generation von Calciumantagonisten ist jetzt verfügbar.
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