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Cancro do pulmão de pequenas células by Wala Ben Kridis, Afef Khanfir

Cancro do pulmão de pequenas células

by Wala Ben Kridis , Afef Khanfir
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Book cover type: Paperback
  • ISBN13: 9786209505539
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 60
  • Original Price: GBP 38.19
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 96 grams
  • BISAC Subject(s): General

O cancro do pulm�o de pequenas c�lulas (SCLC) � uma neoplasia neuroend�crina agressiva, altamente metast�tica e normalmente diagnosticada em est�gios avan�ados, resultando em mau progn�stico. � respons�vel por 13-15% de todos os cancros do pulm�o e est� fortemente associado ao tabagismo. A r�pida progress�o da doen�a, a tend�ncia para desenvolver resist�ncia � quimioterapia e as met�stases frequentes no c�rebro, f�gado e ossos apresentam desafios significativos para o tratamento. A terapia inicial com quimioterapia, principalmente regimes � base de platina, muitas vezes produz boas respostas em doen�as em fase limitada, mas a recidiva ocorre rapidamente na maioria dos pacientes, com a doen�a em fase extensa apresentando benef�cios m�nimos de sobreviv�ncia a longo prazo. Os avan�os recentes na imunoterapia, particularmente os inibidores de pontos de controlo imunit�rios, t�m-se mostrado promissores na melhoria dos resultados, especialmente quando combinados com quimioterapia. Al�m disso, terapias direcionadas a altera��es moleculares espec�ficas, como amplifica��o de MYC e superexpress�o de BCL2, est�o atualmente em investiga��o. As tecnologias de bi�psia l�quida e o perfil molecular est�o a revolucionar a dete��o precoce e o tratamento personalizado, oferecendo esperan�a para melhores estrat�gias de tratamento.

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