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Carboxypeptidases d'Anophèle Et Développement de Plasmodium Falciparum by Lavazec-C

Carboxypeptidases d'Anophèle Et Développement de Plasmodium Falciparum

by Lavazec-C
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Book cover type: Paperback
  • ISBN13: 9783838170442
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 172
  • Original Price: GBP 46.0
  • Language: French
  • Edition: N/A
  • Item Weight: 259 grams
  • BISAC Subject(s): Life Sciences / Biology

L'identification de molécules du moustique Anopheles intervenant dans le développement du parasite Plasmodium pourraient permettre de proposer de nouvelles cibles de blocage de la transmission du parasite responsable du paludisme. Dans cette optique, nous nous sommes intéressés à un gène d'An. gambiae (cpbAg1) surexprimé en présence de Plasmodium falciparum dans le repas de sang de l'insecte. L'analyse biochimique de la protéine recombinante a démontré que CPBAg1 exerce une activité carboxypeptidase B, qui consiste à libérer les résidus arginine et lysine en position carboxy-terminale des protéines. L'ajout d'anticorps dirigés contre CPBAg1 dans un repas infectant inhibe le développement du parasite. Ces résultats suggèrent que l'activité carboxypeptidase B d'An. gambiae, en libérant de l'arginine dans le tube digestif de l'insecte, facilite le développement du parasite. Des essais de vaccination de souris avec la protéine CPBAg1 ont montré que cette protéine pourrait constituer une nouvelle cible vaccinale pour le développer un vaccin anti-transmission basé sur un antigène caractérisé de moustique.

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