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Carcinome hépatocellulaire et thérapies ciblées by Bouhlal-H

Carcinome hépatocellulaire et thérapies ciblées

by Bouhlal-H
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Book cover type: Paperback
  • ISBN13: 9783841786463
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 24.0
  • Language: French
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): General

Le carcinome hépatocellulaire ou hépatocarcinome (CHC) est une prolifération néoplasique d'origine hépatocytaire. Il s'agit de l'un des cancers primitifs du foie les plus fréquents: 7ème cancer le plus fréquent chez l'homme; 9ème chez la femme. Le CHC survient le plus souvent sur une maladie hépatique, cirrhose dans plus de 90 % ou hépatite chronique virale préexistante. Le sorafénib (Nexavar(R)) est un inhibiteur multikinase qui diminue la prolifération des cellules tumorales in vitro. Le sorafénib inhibe l'activité des cibles présentes dans les cellules tumorales (c-KIT, et FLT-3) et la vascularisation tumorale (VEGFR). La tolérance et l'efficacité de Nexavar(R) ont été étudiées chez des patients atteints de carcinome hépatocellulaire (HCC) et chez des patients atteints de carcinome rénal avancé (RCC). Cette efficacité reste cependant encore limitée et il est réservé pour l'instant aux seuls patients Child-Pugh A, OMS 0-2 chez lesquels un traitement à visée curative est contre-indiqué.

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