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Cellules souches et irradiations by Collectif

Cellules souches et irradiations

by Collectif
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Book cover type: Paperback
  • ISBN13: 9783841787125
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 224
  • Original Price: GBP 57.0
  • Language: French
  • Edition: N/A
  • Item Weight: 336 grams
  • BISAC Subject(s): Life Sciences / Biology

Les Cellules souches mésenchymateuses (CSM) possèdent une multi-potentialité et des propriétés de régulation immunologique et inflammatoire. La thérapie cellulaire basée sur leur greffe semble une approche particulièrement prometteuse à l'heure actuelle. Mes travaux ont porté sur la mise en évidence de la recolonisation des tissus murins irradiés par les CSM dérivées de moelle osseuse humaine. J'ai développé au cours de ma thèse des modèles d'irradiation corps entier et localisée sur le modèle murin NOD/SCID et optimisé la greffe de CSM dans ces modèles. Cette étude a permis de mettre en évidence que la migration des CSM dépend de la configuration, de la dose et du temps post-irradiation. L'injection intraveineuse de CSM humaines a permis leur implantation dans un grand nombre d'organes irradiés et de rétablir l'homéostasie intestinale 3 jours post-IA. La biodistribution des CSM après irradiation suggère une migration dose-dépendante préférentielle des CSM vers les organes de la zone surexposée. La thérapie cellulaire basée sur la greffe de CSM semble une approche prometteuse pour le traitement des irradiations accidentelles et même des effets tardifs liés à la radiothérapie.

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