The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry.
Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders.
In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders.
The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.
Edited by Dennis Charney, Dean, Icahn School of Medicine at Mount Sinai, Eric Nestler, Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs, Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System, Joseph D. Buxbaum, Professor, Seaver Autism Center for Research and Treatment Department of Psychiatry Icahn School of Medicine at Mount Sinai, Elisabeth B. Binder, Director, Department of Genes and Environment, Max Planck Institute of Psychiatry, Joshua A. Gordon, Director, National Institute of Mental Health, and Marina R. Picciotto, Professor, Department of Psychiatry, Yale University
Dennis S. Charney, MD, Dean, Icahn School of Medicine at Mount Sinai, President for Academic Affairs, Mount Sinai Health System, Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, New York, NY, USA
Eric J. Nestler, MD, PhD, , Nash Family Professor of Neuroscience, Director, Friedman Brain Institute, Dean for Academic Affairs, Icahn School of Medicine at Mount Sinai, Chief Scientific Officer of the Mount Sinai Health System, New York, NY, USA
Joseph D. Buxbaum, PhD, G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Deputy Chair, Department of Psychiatry, Director, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Elisabeth B. Binder. MD, Director, Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany
Joshua A. Gordon, MD, Director, National Institute of Mental Health, Bethesda, MD, USA
Marina R. Picciotto, Charles B. G. Murphy Professor of Psychiatry and Professor, Child Study Center, of Neuroscience and of Pharmacology, Director, Division of Molecular Psychiatry, Deputy Chair for Basic Science Research, Dept. of Psychiatry, Deputy Director, Kavli Institute for Neuroscience, Co-Director, Neuroscience Research Training Program, Yale Department of Psychiatry, New Haven, CT, USA
