Computer-Aided Vaccine Design
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Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.Dr. Joo Chuan Tong is currently Principal Investigator and Assistant Department Head of the Data Mining Department at A*STAR Institute for Infocomm Research, Singapore. He is also Adjunct Assistant Professor in the Department of Biochemistry at Yong Loo Lin School of Medicine, National University of Singapore.
Professor Shoba Ranganathan is currently Chair Professor of Bioinformatics at Macquarie University, Australia. She is also Adjunct Professor at the National University of Singapore. Her research is focused on bioinformatics analysis at the genome, transcriptome and proteome levels.
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