Computergestützte Ermittlung neuer Biomarker für Darmkrebs

Name: Computergestützte Ermittlung neuer Biomarker für Darmkrebs
Brand: Verlag Unser Wissen
SKU: 9786630030044
Price: 5314.0 INR
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by Ashok Palaniappan

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ISBN13: 9786630030044
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: May 31, 2026
Pages: 56
Original Price: GBP 42.0
Language: German
Edition: N/A
Item Weight: 87 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Diese Arbeit stellt einen neuartigen systembiologischen Ansatz dar, um die Identit�t spezifischer Gene und Genprodukte zu entschl�sseln, die an der Entwicklung von Darmkrebs von der Tumorentstehung bis hin zur Metastasierung beteiligt sind. Es wurde eine stadiumsbasierte Metaanalyse �ffentlich zug�nglicher Tumorgenom-Sequenzierungsdaten durchgef�hrt, und es wurden verschiedene Ans�tze eingesetzt, um neue Gene zu identifizieren, die die Entstehung, das Fortschreiten und die Metastasierung von Darmkrebs vorantreiben. Die konsensbasierten stadiumspezifischen Treibergene bildeten die Grundlage f�r die Konstruktion von ad-hoc-stadiumspezifischen Netzwerken, die hinsichtlich der Zentralit�t der Gene, der Clusterbildung von Subnetzwerken und der Anreicherung von Genontologie-Prozessen analysiert wurden. Neun neue Treibergene wurden als zentral f�r die Entstehung und Tumorentstehung von Darmkrebs identifiziert. Drei, vier bzw. drei neue Treibergene wurden als Knotenpunkte f�r das Fortschreiten in Stadium II, Stadium III und Stadium IV identifiziert. Unsere Ergebnisse wurden durch Subnetzwerkmodule und Ontologieanalysen gest�tzt. Unsere Studie lieferte potenzielle diagnostische Biomarker f�r Darmkrebs sowie neue stadiumspezifische Wirkstoffziele f�r eine rationale Intervention. Unsere Methodik l�sst sich auf die Analyse anderer Krebsarten ausweiten, um die L�cken in unserem Wissen zu schlie en.

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