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Contrôler l'infection par leishmania by Holzmuller-P

Contrôler l'infection par leishmania

by Holzmuller-P
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Book cover type: Paperback
  • ISBN13: 9786131544262
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 332
  • Original Price: GBP 85.0
  • Language: French
  • Edition: N/A
  • Item Weight: 486 grams
  • BISAC Subject(s): Life Sciences / Biology

Les leishmanioses sont des anthropozoonoses dues � un protozoaire du genre Leishmania, parasite dont la forme amastigote colonise les phagocytes mononucl��s des h�tes vert�br�s. La r�sistance aux infections leishmaniennes d�pend de la destruction des parasites intracellulaires par les macrophages activ�s, via la synth�se du monoxyde d'azote (NO). Lorsque la pathologie est d�clar�e, le traitement de la leishmaniose consiste en l'administration d'antimoni�s. Dans ce travail de th�se de doctorat, nous montrons que ces deux mol�cules, NO et antimoine, induise une mort cellulaire apoptotique des leishmanies. Nous montrons �galement que des amastigotes r�sistants � l'antimoine restent sensibles aux m�dicaments anti-leishmaniens de seconde intention, et que le caract�re chimior�sistant peut �tre transmis. Enfin, nous mettons en �vidence l'existence d'une r�sistance crois�e au NO et � l'antimoine, permettant de s�lectionner des formes amastigotes de Leishmania mutantes capables de r�sister � l'effet du NO. La surexpression de cibles mol�culaires du NO chez les mutants ouvre des perspectives d'�tudes pharmacologiques sur de nouveaux principes actifs anti-leishmaniens.

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