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Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications by Zigang Li, Hui Zhao, Chuan Wan

Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications

by Zigang Li , Hui Zhao , Chuan Wan
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Hardcover: Hardcover
  • ISBN13: 9783527343423
  • Binding: Hardcover
  • Subject: N/A
  • Publisher: Wiley
  • Publisher Imprint: Wiley-VCH
  • Publication Date:
  • Pages: 240
  • Original Price: GBP 120.95
  • Language: English
  • Edition: N/A
  • Item Weight: 630 grams
  • BISAC Subject(s): Life Sciences / Biochemistry

An important and timely guide to the progress being made on constrained helical peptides

Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity.

The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic.

This important book: *Offers a practical introduction to constrained helical peptides *Includes all aspects of constrained helical peptides *Includes information on the most recent methods that have emerged *Presents a guide to help solve practical problems in the field

Written for academics, pharmaceutical professional, Cyclized Helical Peptides is a comprehensive guide to the developments of constrained helical peptides.

Zigang Li is a professor in School of Chemical Biology and Biotechnology of Peking University, and the executive deputy director and senior researcher in the Shenzhen Bay Laboratory Pingshan Translational Medicine Center.

Hui Zhao is an investment manager of Shenzhen Angel FOF, with experience in industry research and investment, in the field of innovative drugs and medical devices.

Chuan Wan is a post-doctoral student under the supervision of Prof. Zigang Li.

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